Pyridine → HCID 59377896, compound

Participants

Reaction Steps

To a solution of 2-bromo-4-chloro-5-methylsulfanyl-phenylamine (0.10 g, 0.396 mmol) in toluene (3 ml) was added pyridine (0.042 ml, 0.515 mmol), DMAP (0.048 g, 0.396 mmol) and 20% phosgene in toluene (0.225 ml, 0.436 mmol). The mixture was stirred at room temperature for two hours, then filtered. The filtrate was concentrated to dryness to give 1-bromo-5-chloro-2-isocyanato-4-methylsulfanyl-benzene (0.095 g) as a white solid that was used directly in the next step.

Provenance & Evidence