Phosgene → 3-Bromo-2-isocyanato-6-methoxy-pyridine

HRID 1691837Notes

Reaction equation

[Br:1][C:2]1[C:3]([NH2:10])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.[C:11](Cl)(Cl)=[O:12]>>[Br:1][C:2]1[C:3]([N:10]=[C:11]=[O:12])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6371Phosgene

HCID 234358793-Bromo-6-methoxypyridin-2-amine

Product 1

HCID 593777343-Bromo-2-isocyanato-6-methoxy-pyridine

Procedure

3-Bromo-2-isocyanato-6-methoxy-pyridine was prepared by reaction of 3-bromo-6-methoxy-pyridin-2-ylamine with phosgene using the procedure of step 2 of Example 1.

Sources & evidence

ORD record: ord-5ac2bf4e6c8844c9b8ee8f494b03f87b
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08153809B2

Reaction notes

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