反应详情

1-Isopropenyl-4,5-dimethoxy-2-nitro-benzene (446 mg, 2.0 mmol) was dissolved in 50 ml of methanol at room temperature. 10% Palladium on Carbon (200 mg) was added and the mixture was stirred under a balloon of hydrogen overnight. The mixture was filtered through celite. The filtrate was concentrated in vacuo, and the residue was purified by flash chromatography (4:1 Hexanes/Ethyl Acetate) to give 2-isopropyl-4,5-dimethoxy-phenylamine (369 mg, 94.6%) as a tan oil.

1. filtrationThe mixture was filtered through celite
2. concentrationThe filtrate was concentrated in vacuo
3. customthe residue was purified by flash chromatography (4:1 Hexanes/Ethyl Acetate)