HCID 57652073, compound → HCID 57652026, compound

HRID 1691863Notes

Reaction equation

HRID 1691863 reaction equation
[C:1](OC(N1CC[C@H](NC2C=CC(N)=CN=2)C1)=O)(C)(C)C.[CH3:21][O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24].COC([C@@H]1CC[C@H](NC2C=CC([N+]([O-])=O)=CN=2)C1)=O>>[CH2:21]([O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24])[CH3:1]

Participants

4

Reactant 3

HCID 57652073HCID 57652073, compoundHCID 66738250HCID 66738250, compoundHCID 66738402HCID 66738402, compound

Product 1

HCID 57652026HCID 57652026, compound

Procedure

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (1R,3S)-3-(5-amino-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester was prepared by the hydrogenation of (1R,3S)-3-(5-nitro-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester. This material was directly used in the next step without further purification.

Workup

  1. customThis material was directly used in the next step without further purification

Sources & evidence

ORD record
ord-33f4887b9d49421089b337bea53c504d
Source dataset
uspto-grants-2012_04
Patent number
US08153644B2

Reaction notes

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