参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 氯化亚砜 | HCID 24386 | — |
| 反应物 | 3 - 吡啶甲醇,2,4 - 二甲基 | HCID 10329351 | — |
| 溶剂 | 二氯甲烷 | HCID 6344 | — |
| 产物 | 3-(Chloromethyl)-2,4-dimethylpyridine | HCID 19690977 | — |
反应步骤
The 2,4-dimethyl-3-hydroxymethylpyridine (19.2 g, 140 mmol) was dissolved in CH2Cl2 (800 mL) and cooled under nitrogen to 0° C. and thionyl chloride (125 mL) was slowly added and the reaction was stirred for 18 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate. The organic layer was dried with MgSO4, filtered and the solvent removed under reduced pressure to give the desired 2,4-dimethyl-3-chloromethylpyridine.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 专利号 | US05726172 |
|---|
| 来源数据集 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-bfc9e545236f4da9864ea3f99c2d6fe8 |
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| 来源说明 | uspto-grants-1998_03 |
|---|
