化工社化工社 化学情報印刷レポート · 研究参考用
4-Nitro-3-phenyl-L-alanine → N-(2,6-Dichlorobenzoyl)-4-nitro-L-phenylalanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitro-3-phenyl-L-alanine | HCID 13706 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,6-Dichlorobenzoyl chloride | HCID 78392 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | N-(2,6-Dichlorobenzoyl)-4-nitro-L-phenylalanine | HCID 58018322 | — |
反応手順
Concretely, 4-nitro-L-phenylalanine and 2,6-dichlorobenzoylchloride are condensed in a mixed solvent of a sodium hydroxide aqueous solution and acetone with keeping the reaction temperature at 5 to 15° C., and then crystallization is conducted to obtain a corresponding condensed substance, Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine almost quantitatively.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737274B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-fa9291b9544d4ee1a39d7a61a3b0ea03 |
| 出典メモ | uspto-grants-2010_06 |