Morpholine → HCID 44124590, compound

Participants

Reaction Steps

The title compound was prepared by the method of Example 34, substituting (R)-1-(6-bromobenzo[d]thiazol-2-yl)piperidin-3-yl methanesulfonate (Reference Example 12) in place of (S)-1-(6-bromobenzo[d]thiazol-2-yl)piperidin-3-yl methanesulfonate (Reference Example 10) and substituting morpholine in place of azetidine to give (S)-4-(1-(6-bromobenzo[d]thiazol-2-yl)piperidin-3-yl)morpholine. 1H NMR (300 MHz, CD3OD) δ ppm 1.75-2.01 (m, 2H), 2.02-2.14 (m, 1H), 2.32-2.43 (m, 1H), 3.29-3.48 (m, 3H), 3.50-3.73 (m, 4H), 3.80-3.96 (m, 3H), 4.03-4.19 (m, 2H), 4.56-4.65 (m, 1H), 7.33 (d, J=9 Hz, 1H), 7.39 (dd, J=2, 9 Hz, 1H), 7.79 (d, J=2 Hz, 1H); MS (DCI/NH3) m/z 382 (M+H)+.

Provenance & Evidence