Ammonia → HCID 178515838, compound

Participants

Reaction Steps

The title compound was prepared by the method of Example 73, substituting (R)-6-(6-methoxypyridin-3-yl)-2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazole (Example 19) in place of (R)-6-(2-methoxypyrimidin-5-yl)-2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazole (Example 15). 1H NMR (300 MHz, CD3OD) δ ppm 1.47-1.56 (m, 2H), 1.61-1.72 (m, 4H), 1.96-2.09 (m, 1H), 2.31-2.42 (m, 1H), 2.46-2.65 (m, 4H), 3.03-3.16 (m, 1H), 3.37-3.45 (m, 1H), 3.50-3.61 (m, 1H), 3.70-3.79 (m, 1H), 3.83-3.90 (m, 1H), 6.64 (dd, J=9.5, 0.7 Hz, 1H), 7.45 (dd, J=8.5, 1.7 Hz, 1H), 7.52 (d, J=8.5 Hz, 1H), 7.67 (d, J=2.0 Hz, 1H), 7.84 (d, J=2.0 Hz, 1H), 7.96 (dd, J=9.5, 2.7 Hz, 1H); MS (DCI/NH3) m/z 381 (M+H)+.

Provenance & Evidence