Lithium Hydroxide → HCID 66904958, compound

Participants

Reaction Steps

Treat a solution of 3′-Chloro-4′-[(R)-2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid methyl ester (0.76 g) in THF (15 mL) with 2N LiOH (15 mL) at room temperature for 5 hours. Partition the mixture between ethyl acetate (25 mL) and 1 N HCl (10 mL). Dry the organic layer with Na2SO4 and remove the solvent in vacuo to afford 0.73 g (98%) of the title compound. MS (m/z): 585 (M+).

Provenance & Evidence