1,1'-Carbonyldiimidazole → HCID 57672047, compound

Participants

Reaction Steps

Treat a mixture of (R)-3′,5′-dichloro-4′-(1-morpholin-4-yl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid trifluoro acetate (0.16 g, 0.28 mmol) in CH2Cl2 (10 mL) with 1,1′-carbonyldiimidazole (0.092 g, 0.57 mmol), 4-trifluoromethylpiperidine hydrochloride (0.081 g, 0.43 mmol) and diisopropylethylamine (0.110 g, 0.86 mmol) and stir for 12 hours at room temperature. Load the mixture on silica gel column and flash with 50% ethyl acetate in hexanes to 100% ethyl acetate to afford 0.081 g of a mixture of the title compound and impurity. Re-purify via reverse phase HPLC to afford 0.055 g (34%) of the title compound. MS (m/z): 584 (M+).

Provenance & Evidence