Water → HCID 57672052, compound

Participants

Reaction Steps

Add water (6 mL) and TFA (2 mL) to (R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide (0.21 g) in THF (6 mL). Stir the mixture at room temperature for 12 hours. Dilute the reaction with ethyl acetate and wash with sodium bicarbonate (sat. solution), separate the organic layer, dry over sodium sulfate, filter and concentrate. Purify the residue on silica gel column by using ethyl acetate first, then switch to 5% methanol in dichloromethane to afford 0.158 g (100%) of the desired product as white solid. MS (m/z): 478 (M+).

Provenance & Evidence