Water → HCID 66905198, compound

Participants

Reaction Steps

Treat a mixture of (R)-3-[3′-chloro-4′-(4-trifluoromethyl-piperidine-1-carbonyl)-biphenyl-4-ylmethyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (0.12 g), THF (3 mL) and water (3 mL) with TFA (1 mL) at room temperature for 5 hours. Dilute the reaction with ethyl acetate and wash with sodium bicarbonate (sat.). Dry the organic layer (Na2SO4), remove the solvent in vacuo to afford crude product, and purify on silica gel column with 100% ethyl acetate and 10% methanol in methylene chloride to afford 0.05 g (53%) of the titled product. MS (m/z): 564 (M+).

Provenance & Evidence