3-cyano-4-[2-(5-methyl-1-trityl-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide → 3-cyano-4-[2-(5-methyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

HRID 1692209Notes

Reaction equation

HRID 1692209 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([S:45]([NH:48][C:49]2[S:53][N:52]=[CH:51][N:50]=2)(=[O:47])=[O:46])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=1[C:20]1[CH:21]=[N:22][N:23](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[C:24]=1[CH3:25])#[N:2]>Cl.O1CCOCC1>[C:1]([C:3]1[CH:4]=[C:5]([S:45]([NH:48][C:49]2[S:53][N:52]=[CH:51][N:50]=2)(=[O:47])=[O:46])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:17])[F:18])=[CH:12][C:11]=1[C:20]1[CH:21]=[N:22][NH:23][C:24]=1[CH3:25])#[N:2]

Participants

4

Reactant 1

HCID 594365913-cyano-4-[2-(5-methyl-1-trityl-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Product 1

HCID 574948223-cyano-4-[2-(5-methyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

3-cyano-4-[2-(5-methyl-1-trityl-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide (Preparation 428, 345 mg, 0.46 mmol) was dissolved in 4N HCl in 1,4-dioxane (5 ml) and stirred at room temperature for 3 hours before concentrating in vacuo. The residue obtained was purified using an ISCO™ (12 g SiO2) eluting with methanol:dichloromethane (gradient 0:1 to 1:9, by volume). The purified compound was triturated with dichloromethane (10 mL) to afford the title compound as a white solid (148 mg, 34%—isolated as the hydrochloride salt).

Workup

  1. concentrationbefore concentrating in vacuo
  2. customThe residue obtained
  3. customwas purified
  4. washeluting with methanol
  5. customThe purified compound was triturated with dichloromethane (10 mL)

Sources & evidence

ORD record
ord-41abc8c371f8456099982c6deafdb40a
Source dataset
uspto-grants-2012_04
Patent number
US08153814B2

Reaction notes

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