HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 4-Hydroxy-3-iodobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Cyanophenol | HCID 13019 | — |
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Hydroxy-3-iodobenzonitrile | HCID 10955815 | — |
Reaction Steps
4-Hydroxy-3-iodobenzonitrile was prepared by the method analogous to Preparation 341 above using N-iodosuccinimide, acetic acid, sulfuric acid and 4-Hydroxybenzonitrile. Purified by ISCO™ (80 g SiO2) eluting with ethyl acetate:heptane (gradient 0:1 to 3:7, by volume) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153814B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-237f7a44c8db4f6eab35b1cdc50187e7 |
| Source note | uspto-grants-2012_04 |