HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → (3,5-Dimethyl-3'-trifluoromethoxy-biphenyl-4-yl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734385 | — |
| Reactant | 2-(1,4-Diazepan-1-yl)ethan-1-ol | HCID 2736550 | — |
| Reactant | 4-Bromo-2,6-dimethylbenzoic acid | HCID 11959006 | — |
| Reactant | (4-Bromo-2,6-dimethyl-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 66901599 | — |
| Reactant | (4-Bromo-2,6-dimethyl-phenyl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone | HCID 66901627 | — |
| Product | (3,5-Dimethyl-3'-trifluoromethoxy-biphenyl-4-yl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone | HCID 57580538 | — |
Reaction Steps
In analogy to the procedure described for example 1, (4-bromo-2,6-dimethyl-phenyl)-[4-(2-hydroxy-ethyl)-[1,4]diazepan-1-yl]-methanone (prepared from 4-bromo-2,6-dimethyl-benzoic acid and 2-[1,4]diazepan-1-yl-ethanol in analogy to the procedure described for the preparation of intermediate 1) was reacted with 3-trifluoromethoxy-phenyl boronic acid to give the title compound as light yellow amorphous solid. MS: 437.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153805B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-de415f3200804c1eadbd6c409df66318 |
| Source note | uspto-grants-2012_04 |