3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 57580537, compound

HRID 1692397Notes

Reaction equation

HRID 1692397 reaction equation
Br[C:2]1[C:3]([CH3:21])=[C:4]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])[CH:5]=[CH:6][CH:7]=1.[F:22][C:23]([F:35])([F:34])[O:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1>>[CH3:21][C:3]1[C:4]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])=[CH:5][CH:6]=[CH:7][C:2]=1[C:27]1[CH:28]=[CH:29][CH:30]=[C:25]([O:24][C:23]([F:22])([F:34])[F:35])[CH:26]=1

Participants

3

Reactant 2

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 65573179HCID 65573179, compound2×

Product 1

HCID 57580537HCID 57580537, compound

Procedure

In analogy to the procedure described for example 1, (3-bromo-2-methyl-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (intermediate 2) was reacted with 3-trifluoromethoxy-phenyl boronic acid to give the title compound as dark brown amorphous solid. MS: 433.3 (MH+).

Sources & evidence

ORD record
ord-bc050d0878794829ac9ce2f4220534f7
Source dataset
uspto-grants-2012_04
Patent number
US08153805B2

Reaction notes

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