3-(Trifluoromethyl)phenylboronic acid → HCID 57580522, compound

HRID 1692398Notes

Reaction equation

HRID 1692398 reaction equation
Br[C:2]1[C:3]([CH3:21])=[C:4]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])[CH:5]=[CH:6][CH:7]=1.[F:22][C:23]([F:34])([F:33])[C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1>>[CH3:21][C:3]1[C:4]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])=[CH:5][CH:6]=[CH:7][C:2]=1[C:28]1[CH:27]=[CH:26][CH:25]=[C:24]([C:23]([F:34])([F:33])[F:22])[CH:29]=1

Participants

3

Reactant 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 65573179HCID 65573179, compound2×

Product 1

HCID 57580522HCID 57580522, compound

Procedure

In analogy to the procedure described for example 1, (3-bromo-2-methyl-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (intermediate 2) was reacted with 3-trifluoromethyl-phenyl boronic acid to give the title compound as dark brown amorphous solid. MS: 417.3 (MH+).

Sources & evidence

ORD record
ord-72c42922daa74b23a0c2321e63340f12
Source dataset
uspto-grants-2012_04
Patent number
US08153805B2

Reaction notes

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