4-(1-Pyrrolidinyl)piperidine → HCID 57580551, compound
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][CH:13]([N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([CH3:21])[CH:3]=1.BrC1C=CC(C(O)=O)=C(C)C=1.N1(C2CCNCC2)CCCC1.BrC1C(C)=C(C(N2CCC(N3CCCC3)CC2)=O)C=CC=1.[F:65][C:66]([F:77])([F:76])[C:67]1[CH:68]=[C:69](B(O)O)[CH:70]=[CH:71][CH:72]=1>>[CH3:21][C:4]1[CH:3]=[C:2]([C:71]2[CH:70]=[CH:69][CH:68]=[C:67]([C:66]([F:77])([F:76])[F:65])[CH:72]=2)[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:15][CH2:14][CH:13]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:12][CH2:11]1)=[O:9]Participants
6
Procedure
In analogy to the procedure described for example 1, (4-bromo-2-methyl-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (prepared from 4-bromo-2-methyl-benzoic acid and 4-pyrrolidin-1-yl-piperidine in analogy to the procedure described for the preparation of intermediate 2) was reacted with 3-trifluoromethyl-phenyl boronic acid to give the title compound as off-white amorphous solid. MS: 417.4 (MH+).
Sources & evidence
- ORD record
- ord-088bb7a3f7104625b95d96b9e3b40f87
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08153805B2
Reaction notes
Loading…