4-(1-Pyrrolidinyl)piperidine → HCID 57580543, compound

Participants

Reaction Steps

In analogy to the procedure described for intermediate 1,2,4-dimethyl-3′-trifluoromethoxy-biphenyl-3-carboxylic acid (prepared from 3-bromo-2,6-dimethyl-benzoic acid [Lee, J.; et al. Bioorganic & Medicinal Chemistry Letters (2003), 13(11), 1879-1882] and 3-trifluoromethoxy-phenyl boronic acid in analogy to the procedure described for the preparation of example 1) was converted into its acid chloride and reacted with 4-pyrrolidin-1-yl-piperidine to give the title compound as light yellow solid. MS: 447.3 (MH+).

Provenance & Evidence