HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethoxy)phenylboronic acid → (3,5-Dimethyl-4'-trifluoromethoxy-biphenyl-4-yl)-(4-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethoxy)phenylboronic acid | HCID 2734386 | — |
| Reactant | (4-Bromo-2,6-dimethyl-phenyl)-(4-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone | HCID 66901547 | — |
| Product | (3,5-Dimethyl-4'-trifluoromethoxy-biphenyl-4-yl)-(4-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone | HCID 57580521 | — |
Reaction Steps
In analogy to the procedure described for example 1, (4-bromo-2,6-dimethyl-phenyl)-(4-hydroxy-[1,4′]bipiperidinyl-1′-yl)-methanone (example 22) was reacted with 4-trifluoromethoxy-phenyl boronic acid to give the title compound as light yellow solid. MS: 477.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153805B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-09ddef9085794a1dbd1f84ca7fd7e7d6 |
| Source note | uspto-grants-2012_04 |