3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine → [2,6-Dimethyl-4-(5-trifluoromethyl-pyridin-3-yl)-phenyl]-(4-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone

Participants

Reaction Steps

In analogy to the procedure described for example 1, (4-bromo-2,6-dimethyl-phenyl)-(4-hydroxy-[1,4′]bipiperidinyl-1′-yl)-methanone (example 22) was reacted with 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-pyridine (intermediate 6) to give the title compound as light yellow oil. MS: 462.2 (MH+).

Provenance & Evidence