HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-Pyrrolidinyl)piperidine → HCID 57580529, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-Pyrrolidinyl)piperidine | HCID 78703 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-(Trifluoromethoxy)benzene-1-carboximidamide--hydrogen chloride (1/1) | HCID 22563503 | — |
| Reactant | HCID 66901575 | HCID 66901575 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 57580529 | HCID 57580529 | — |
Reaction Steps
In analogy to the procedure described for intermediate 2,4-cyclopropyl-6-methyl-2-(3-trifluoromethoxy-phenyl)-pyrimidine-5-carboxylic acid [prepared in analogy to the preparation of 4-cyclopropyl-6-methyl-2-(3-trifluoromethyl-phenyl)-pyrimidine-5-carboxylic acid (intermediate 7), by using 3-trifluoromethoxy-benzamidine hydrochloride instead of 3-trifluoromethyl-benzamidine hydrochloride in the reaction step analogous to the preparation of intermediate 7A] was reacted with HATU, triethylamine and 4-pyrrolidin-1-yl-piperidine in DMF. Subsequent purification by preparative HPLC afforded the title compound as a gum. MS: 475.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153805B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-405acaa60ed1430fadb7e483d450006a |
| Source note | uspto-grants-2012_04 |