3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 57580541, compound

HRID 1692426Notes

Reaction equation

HRID 1692426 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][CH:14]([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:22])[CH:3]=1.[F:23][C:24]([F:36])([F:35])[O:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[F:22][C:4]1[CH:3]=[C:2]([C:28]2[CH:29]=[CH:30][CH:31]=[C:26]([O:25][C:24]([F:23])([F:35])[F:36])[CH:27]=2)[CH:7]=[C:6]([F:8])[C:5]=1[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:13][CH2:12]1)=[O:10]

Participants

3

Reactant 2

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 66901562HCID 66901562, compound

Product 1

HCID 57580541HCID 57580541, compound

Procedure

In analogy to the procedure described for example 1, (4-bromo-2,6-difluoro-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 39) was reacted with 3-trifluoromethoxy-phenyl boronic acid to give the title compound as colorless oil. MS: 455.5 (MH+).

Sources & evidence

ORD record
ord-d3dc6144bf7c41e390af84499f8deb8d
Source dataset
uspto-grants-2012_04
Patent number
US08153805B2

Reaction notes

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