4-(Trifluoromethoxy)phenylboronic acid → HCID 57580542, compound

HRID 1692427Notes

Reaction equation

HRID 1692427 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][CH:14]([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:22])[CH:3]=1.[F:23][C:24]([F:36])([F:35])[O:25][C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1>>[F:22][C:4]1[CH:3]=[C:2]([C:29]2[CH:28]=[CH:27][C:26]([O:25][C:24]([F:23])([F:35])[F:36])=[CH:31][CH:30]=2)[CH:7]=[C:6]([F:8])[C:5]=1[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:13][CH2:12]1)=[O:10]

Participants

3

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 66901562HCID 66901562, compound

Product 1

HCID 57580542HCID 57580542, compound

Procedure

In analogy to the procedure described for example 1, (4-bromo-2,6-difluoro-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 39) was reacted with 4-trifluoromethoxy-phenyl boronic acid to give the title compound as light yellow amorphous solid. MS: 455.5 (MH+).

Sources & evidence

ORD record
ord-582cc1afa69c4fb9a08a755c510bd23c
Source dataset
uspto-grants-2012_04
Patent number
US08153805B2

Reaction notes

Loading…