(4,6-Dimethyl-5'-trifluoromethyl-[2,3']bipyridinyl-5-yl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone → benzoic acid (S)-1-[1-(4,6-dimethyl-5'-trifluoromethyl-[2,3']bipyridinyl-5-carbonyl)-piperidin-4-yl]-pyrrolidin-2-ylmethyl ester

Participants

Reaction Steps

In analogy to the procedures described for intermediate 1 and for intermediate 4B,4,6-dimethyl-5′-trifluoromethyl-[2,3′]bipyridinyl-5-carboxylic acid (example 42) was converted into its acid chloride and reacted with benzoic acid (S)-1-piperidin-4-yl-pyrrolidin-2-ylmethyl ester (intermediate 3) to give benzoic acid (S)-1-[1-(4,6-dimethyl-5′-trifluoromethyl-[2,3′]bipyridinyl-5-carbonyl)-piperidin-4-yl]-pyrrolidin-2-ylmethyl ester, which was subsequently saponified to give the title compound as colorless amorphous solid. MS: 463.2 (MH+).

Provenance & Evidence