4-(1-Pyrrolidinyl)piperidine → HCID 57580553, compound

HRID 1692431Notes

Reaction equation

HRID 1692431 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[CH:6]=[C:7]([CH3:12])[C:8]=1[C:9](O)=[O:10].[N:23]1([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:20])([F:21])[F:22])[CH:14]=2)[CH:6]=[C:7]([CH3:12])[C:8]=1[C:9]([N:31]1[CH2:32][CH2:33][CH:28]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:29][CH2:30]1)=[O:10]

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 66901561HCID 66901561, compound2×

Product 1

HCID 57580553HCID 57580553, compound

Procedure

In analogy to the procedure described for intermediate 1,3-methoxy-5-methyl-3′-trifluoromethyl-biphenyl-4-carboxylic acid (intermediate 10) was converted into its acid chloride and reacted with 4-pyrrolidin-1-yl-piperidine to give the title compound as colorless amorphous solid. MS: 447.1 (MH+).

Sources & evidence

ORD record
ord-bb21087d1da548b2a7039a0fca12f6f1
Source dataset
uspto-grants-2012_04
Patent number
US08153805B2

Reaction notes

Loading…