Boron tribromide → HCID 57580517, compound

Participants

Reaction Steps

To a solution of 0.51 g (1.1 mmol) of (3-methoxy-5-methyl-3′-trifluoromethyl-biphenyl-4-yl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 44) in 15 ml of CH2Cl2 was added at 0° C. 0.39 ml=0.57 g (2.3 mmol) of a boron tribromide solution (1.0 molar in CH2Cl2) drop by drop and the reaction mixture was the warmed up to RT. After 4 hours, it was poured into crashed ice, neutralized with sodium hydrogen carbonate solution and extracted twice with CH2Cl2; the organic phases were washed with water, dried over magnesium sulfate, filtered and evaporated. The residue was purified by flash column chromatography (CH2Cl2/MeOH 1:0 to 4:1) to give 0.18 g (36%) of the title compound as colorless amorphous solid. MS: 433.2 (MH+).

Provenance & Evidence