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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1692437Generated: October 30, 2026

Potassium Phosphate, Tribasic → HCID 57580550, compound

https://huagongshe.com/reaction/1692437

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium Phosphate, TribasicHCID 62657—
Reactant4-(1-Pyrrolidinyl)piperidineHCID 78703—
Reactant3-(Trifluoromethyl)phenylboronic acidHCID 2734388—
Reactant4-Bromo-2-methoxybenzoic acidHCID 13450755—
ReactantHCID 65573179HCID 65573179—
ReactantHCID 66901675HCID 66901675—
CatalystTetrakis(triphenylphosphine)palladiumHCID 11979704—
SolventDimethylformamideHCID 6228—
ProductHCID 57580550HCID 57580550—

Reaction Steps

In analogy to the procedure described in example 1, (4-bromo-2-methoxy-phenyl)-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (prepared from 4-bromo-2-methoxybenzoic acid and 4-pyrrolidin-1-yl-piperidine in analogy to the procedure described for the preparation of intermediate 2), was reacted with 3-trifluoromethyl-phenyl boronic acid, potassium phosphate solution and tetrakis-(triphenylphosphine)-palladium in DMF at 80° C. to give the title compound as colorless oil. MS: 433.2 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153805B2
Source datasetuspto-grants-2012_04
ORD IDord-bc18c7be06c84bd7bec0f97ce201fca4
Source noteuspto-grants-2012_04