反应详情

Sodium hydroxide (22 mg, 0.50 mmol) was added to Methyl N-{4-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2-(trifluoromethyl)benzoyl}glycinate (130 mg, 0.22 mmol) in Water (1 ml) and EtOH (5 ml), and stirred at ambient temperature for overnight. 2NHCl was added into the mixture, and extracted with t-BuOMe three times, and dried over MgSO4. After evaporated, the crude product was got (120.0 mg, 94%).

1. addition2NHCl was added into the mixture
2. extractionextracted with t-BuOMe three times
3. dry with materialdried over MgSO4
4. customAfter evaporated