Hydrogen chloride-ethyl acetate → HCID 67279857, compound

HRID 1692601Notes

Reaction equation

HRID 1692601 reaction equation
[CH3:1][CH:2]1[N:8]([CH3:9])[CH2:7][C:6]2[CH:10]=[CH:11][C:12]([N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)=[N:13][C:5]=2[O:4][CH2:3]1.[ClH:27].C(OCC)(=O)C>>[ClH:27].[ClH:27].[ClH:27].[CH3:1][CH:2]1[N:8]([CH3:9])[CH2:7][C:6]2[CH:10]=[CH:11][C:12]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:13][C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57697642HCID 57697642, compound

Product 1

HCID 67279857HCID 67279857, compoundYield 71%

Procedure

The compound (0.086 g) obtained in Example 23 in 4N hydrogen chloride/ethyl acetate (3.0 mL) was stirred at room temperature for 2 hr. The precipitate was collected by filtration, and recrystallized from MeOH-ethyl acetate to give the title compound (0.063 g, 71%) as a white powder.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customrecrystallized from MeOH-ethyl acetate

Sources & evidence

ORD record
ord-5ecb8debe4ab4c45bf3951015a91dbff
Source dataset
uspto-grants-2012_04
Patent number
US08158617B2

Reaction notes

Loading…