反应详情

To a solution of the compound (0.10 g) obtained in step 1 in ethanol (1 mL) was added hydrobromic acid-ethanol solution (1 mL), and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated under reduced pressure, and the aqueous layer was made basic with ethyl acetate and aqueous sodium hydroxide solution. The organic layer was washed with brine and dried, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the residue, and hydrobromic acid-ethanol solution was added. The precipitate was collected by filtration to give the title compound (0.03 g, 25%) as a white powder.

1. customThe solvent was evaporated under reduced pressure
2. washThe organic layer was washed with brine
3. customdried
4. customthe solvent was evaporated under reduced pressure
5. additionEthyl acetate was added to the residue, and hydrobromic acid-ethanol solution
6. additionwas added
7. filtrationThe precipitate was collected by filtration