Sodium Hydroxide → HCID 3727890, compound

HRID 1692642Notes

Reaction equation

HRID 1692642 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([C:12]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:13]=1Cl)=[O:11].[OH-].[Na+]>O>[CH3:8][C:6]1[CH:5]=[CH:4][C:3]2[NH:9][C:10](=[O:11])[C:12]3[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:13]=3[O:1][C:2]=2[CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 4668642HCID 4668642, compound

Product 1

HCID 3727890HCID 3727890, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of N-(2-Hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzene carboxamide (530 mg, 1.7 mmol) and 2 N NaOH (0.95 ml, 1.9 mol) in water (5 ml) was heated under reflux for 10 h. The resultant slurry was allowed to stand overnight at room temperature and a copious amount of water was added. The resulting mixture was filtered and solid was collected to obtain the compound (380 mg, 83%). Mp: 274-277° C.

Workup

  1. temperatureunder reflux for 10 h
  2. filtrationThe resulting mixture was filtered
  3. customsolid was collected

Sources & evidence

ORD record
ord-733dc83fb55043aaa29901b9a0f41358
Source dataset
uspto-grants-2012_04
Patent number
US08158623B2

Reaction notes

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