HRID1692660

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID17750211

(2-Aminopyrimidin-5-yl)boronic acid

C4H6BN3O2

结构：CC(C)(O)c1nc2c(N3CCOCC3)nc(Cl)nc2n1CCCO[Si](C)(C)C(C)(C)C

HCID86637237

未命名化合物

结构：CC(C)(O)c1nc2c(N3CCOCC3)nc(Cl)nc2[nH]1

HCID178458928

未命名化合物

PRODUCTS

生成物

结构：CC(C)(O)c1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1CCCO

HCID44545042

未命名化合物

PROCEDURE

实验过程

100 mg of 2-(2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol was treated with TBDMS-protected bromopropanol via General Procedure C. Crude intermediate 2-(9-(3-(tert-butyldimethylsilyloxy)propyl)-2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol was treated with 2-aminopyrimidine-5-boronic acid, pinacol ester via General Procedure A and was purified via reverse phase HPLC to give 36 mg of 105 as a white solid. MS (Q1) 415.2 (M)+.

WORKUP

后处理

customwas purified via reverse phase HPLC