HRID1692662

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13564

ETHANOL, 2-BROMO-, ACETATE

C4H7BrO2

HCID17750211

(2-Aminopyrimidin-5-yl)boronic acid

C4H6BN3O2

结构：CC(=O)OCCn1c(C(C)(C)O)nc2c(N3CCOCC3)nc(Cl)nc21

HCID58015224

未命名化合物

结构：CC(C)(O)c1nc2c(N3CCOCC3)nc(Cl)nc2[nH]1

HCID178458928

未命名化合物

PRODUCTS

生成物

结构：CC(C)(O)c1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1CCCO

HCID44545042

未命名化合物

PROCEDURE

实验过程

100 mg of 2-(2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol was treated with 2-bromoethyl acetate via General Procedure C. Crude intermediate 2-(2-chloro-8-(2-hydroxypropan-2-yl)-6-morpholino-9H-purin-9-yl)ethyl acetate was treated with 2-aminopyrimidine-5-boronic acid, pinacol ester via General Procedure A and was purified via reverse phase HPLC to give 54 mg of 106 as a white solid. MS (Q1) 401.2 (M)+.

WORKUP

后处理

customwas purified via reverse phase HPLC