HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetamidophenylboronic acid → N-(4-(9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-6-morpholino-9H-purin-2-yl)phenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetamidophenylboronic acid | HCID 2734657 | — |
| Reactant | 4-(2-Chloro-9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9H-purin-6-yl)morpholine | HCID 86637242 | — |
| Product | N-(4-(9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-6-morpholino-9H-purin-2-yl)phenyl)acetamide | HCID 44543872 | — |
Reaction Steps
4-(2-Chloro-9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9H-purin-6-yl)morpholine (50 mg) was reacted with 4-acetamidophenylboronic acid via General Procedure A and purified via reverse phase HPLC to give 25.9 mg 134 as a white solid. MS (Q1) 529.3 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158624B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-2107566c324c487ea4609feb79f19683 |
| Source note | uspto-grants-2012_04 |