HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxypyrimidine-5-boronic acid → 4-(2-(2-methoxypyrimidin-5-yl)-9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9H-purin-6-yl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxypyrimidine-5-boronic acid | HCID 2736778 | — |
| Reactant | 4-(2-Chloro-9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9H-purin-6-yl)morpholine | HCID 86637242 | — |
| Product | 4-(2-(2-methoxypyrimidin-5-yl)-9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9H-purin-6-yl)morpholine | HCID 44543875 | — |
Reaction Steps
4-(2-Chloro-9-methyl-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9H-purin-6-yl)morpholine (50 mg) was reacted with 2-methoxypyrimidin-5-ylboronic acid via General Procedure A and purified via reverse phase HPLC to give 5.5 mg 136 as a white solid. MS (Q1) 504.3 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158624B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-65cc69722f1942498c89cc23b66e2f9e |
| Source note | uspto-grants-2012_04 |