Propanoyl chloride, 3-bromo- → HCID 49847740, compound

HRID 1692725Notes

Reaction equation

HRID 1692725 reaction equation
[C:1]([C:5]1[C:6]([O:30][CH3:31])=[C:7](/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][C:22]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])=[CH:21][CH:20]=2)[CH:8]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br[CH2:33]CC(Cl)=O>>[C:1]([C:5]1[C:6]([O:30][CH3:31])=[C:7](/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][C:22]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])=[CH:21][CH:20]=2)[CH:8]=[C:9]([N:11]2[CH2:33][CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:10]=1)([CH3:3])([CH3:2])[CH3:4]

Participants

3

Reactant 2

HCID 84944Propanoyl chloride, 3-bromo-HCID 67280361HCID 67280361, compound

Product 1

HCID 49847740HCID 49847740, compound

Procedure

N-(4-{(E)-2-[3-tert-Butyl-2-methoxy-5-(2-oxo-pyrrolidin-1-yl)-phenyl]-vinyl}-phenyl)-methanesulfonamide can be prepared analogously except in step 2,4-bromo-butyryl chloride is replaced with 3-bromo-propionyl chloride.

Sources & evidence

ORD record
ord-3394f06f21984c44a015d88b80688ae1
Source dataset
uspto-grants-2012_04
Patent number
US08158631B2

Reaction notes

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