反应详情

18 ml of 30% strength hydrogen peroxide solution are added to a solution of 5-amino-1-cyclohexyl-1H-pyrazole-4-carbonitrile (1.86 g, 9.81 mmol) in a mixture of 73 ml of ethanol and 90 ml of concentrated aqueous ammonia solution at room temperature, and the mixture is stirred at room temperature for 1 h. The nonaqueous solvents are then stripped off in a rotary evaporator. The product precipitates as solid from the remaining mixture and is filtered off with suction, washed with a little water and dried under high vacuum.

1. customThe nonaqueous solvents are then stripped off in a rotary evaporator
2. customThe product precipitates as solid from the remaining mixture
3. filtrationis filtered off with suction
4. washwashed with a little water
5. customdried under high vacuum