HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-(2-(2-Methoxypropan-2-yl)-7-morpholinothiazolo[5,4-d]pyrimidin-5-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine-5-boronic acid, pinacol ester | HCID 17750212 | — |
| Reactant | 4-(5-Chloro-2-(2-methoxypropan-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine | HCID 86630067 | — |
| Product | 5-(2-(2-Methoxypropan-2-yl)-7-morpholinothiazolo[5,4-d]pyrimidin-5-yl)pyrimidin-2-amine | HCID 25253992 | — |
Reaction Steps
Crude 4-(5-chloro-2-(2-methoxypropan-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine (60 mg) was reacted with 2-aminopyrimidine-5-boronic acid pinacol ester via general procedure A with to get 55 mg 104 following reverse phase HPLC purification. MS (Q1) 388.2 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158626B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-972da0dbb81948f0a0482cdef9614610 |
| Source note | uspto-grants-2012_04 |