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HRID1692770

反应详情

EQUATION

反应方程式

HRID 1692770 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2ccc(N)nc2)OC1(C)C
HCID2756555

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

C11H17BN2O2

结构：CS(=O)(=O)N1CCN(Cc2nc3c(N4CCOCC4)nc(Cl)nc3s2)CC1
HCID44541675

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)N1CCN(Cc2nc3c(N4CCOCC4)nc(-c4ccc(N)nc4)nc3s2)CC1
HCID25254151

未命名化合物

收率 26.8%

PROCEDURE

实验过程

5-Chloro-2-(4-methanesulfonyl-piperazin-1-ylmethyl)-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine (80 mg) was reacted with 49 mg of 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine via General Procedure A. The product was purified by reverse phase HPLC to yield 24.3 mg of 111. MS (Q1) 491.0 (M)+.

WORKUP

后处理

  1. customThe product was purified by reverse phase HPLC