1-(2-Hydroxyethyl)piperazine → 2-(4-(5-Chloro-7-morpholinothiazolo[4,5-d]pyrimidin-2-yl)piperazin-1-yl)ethanol

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Hydroxyethyl)piperazine	HCID 7677	—
Reactant	5-Chloro-2-(methylsulfonyl)-7-morpholinothiazolo[4,5-d]pyrimidine	HCID 57685406	—
Product	2-(4-(5-Chloro-7-morpholinothiazolo[4,5-d]pyrimidin-2-yl)piperazin-1-yl)ethanol	HCID 86630078	—

Reaction Steps

5-Chloro-2-(methylsulfonyl)-7-morpholinothiazolo[4,5-d]pyrimidine was reacted with 2-(piperazin-1-yl)ethanol, via General Procedure C, to give crude 2-(4-(5-chloro-7-morpholinothiazolo[4,5-d]pyrimidin-2-yl)piperazin-1-yl)ethanol, which was then reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure C again to give 134 after purification by reverse HPLC. MS (Q1) 444 (M+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08158626B2
Source dataset	uspto-grants-2012_04
ORD ID	ord-8bf47ad698074a46ad9926c8f92c7244
Source note	uspto-grants-2012_04