HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 5-Chloro-2-(4-methoxypyridin-3-yl)-7-morpholinothiazolo[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-(5-Chloro-2-iodothiazolo[4,5-d]pyrimidin-7-yl)morpholine | HCID 25252763 | — |
| Reactant | 4-Methoxypyridine-3-boronic acid monohydrate | HCID 44119671 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Chloro-2-(4-methoxypyridin-3-yl)-7-morpholinothiazolo[4,5-d]pyrimidine | HCID 86630084 | — |
Reaction Steps
5-Chloro-2-iodo-7-morpholinothiazolo[4,5-d]pyrimidine, 4-methoxypyridine-3-boronic acid hydrate, and trans-dichlorobis(triphenylphosphine)palladium(II) (0.1 eq) were slurried with equal parts 1M sodium carbonate aqueous solution (3 eq) and acetonitrile. The solution was microwaved at 100° C. for 10 minutes. Water was added and the solution was filtered to give the product 5-chloro-2-(4-methoxypyridin-3-yl)-7-morpholinothiazolo[4,5-d]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158626B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-78fdd7f73ad84374b8defe88d0fe9088 |
| Source note | uspto-grants-2012_04 |