HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-Methoxy-7h-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| Reactant | 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 5706774 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Methoxy-7h-pyrrolo[2,3-d]pyrimidine | HCID 248792 | — |
| Product | 2-Methoxy-7H-pyrrolo[2,3-d]pyrimidine | HCID 10103317 | — |
Reaction Steps
4-methoxy-7H-pyrrolo[2,3-d]pyrimidine (3) or 2-methoxy-7H-pyrrolo[2,3-d]pyrimidine (4) is prepared by reacting 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1) or 2-chloro-7H-pyrrolo[2,3-d]pyrimidine (2), respectively, with sodium hydroxide in methanol as described by Girgis, N. et. al., J. Heterocyclic. Chem. 1989, 26:317-325.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158636B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-ac18e9461f7446688a31b3cc6e268951 |
| Source note | uspto-grants-2012_04 |