HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-bromo-7H-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine | HCID 261591 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-bromo-7H-pyrrolo[2,3-d]pyrimidine | HCID 10798005 | — |
Reaction Steps
5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (7) is prepared by dissolving 7H-pyrrolo[2,3-d]pyrimidine (6) in chloroform and slowly adding Br2 in carbon tetrachloride at 0° C. After stirring for 1-2 hours, the reaction may be quenched in aqueous hydrochloric acid. Isolation by conventional means (e.g. extraction and silica gel chromatography) provides compound 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158636B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6770d5bd80944e549483bd9be3226cdf |
| Source note | uspto-grants-2012_04 |