HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1692812Generated: October 26, 2026
Nitric Acid → 5-nitro-7H-pyrrolo[2,3-d]pyrimidine
https://huagongshe.com/reaction/1692812
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine | HCID 261591 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-nitro-7H-pyrrolo[2,3-d]pyrimidine | HCID 57963148 | — |
Reaction Steps
5-Nitro-7H-pyrrolo[2,3-d]pyrimidine (8) is prepared by adding 7H-pyrrolo[2,3-d]pyrimidine (6) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 5-nitro-7H-pyrrolo[2,3-d]pyrimidine 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08158636B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-fdd97b2539cb4712bd10423fa3a30dba |
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| Source note | uspto-grants-2012_04 |
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