HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 5-Amino-1-methyl-1H-imidazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 5-amino-1-methyl-1H-imidazole-4-carbonitrile | HCID 11051635 | — |
| Product | 5-Amino-1-methyl-1H-imidazole-4-carboxamide | HCID 6420287 | — |
Reaction Steps
The cyano group of 5-amino-1-methyl-1H-imidazole-4-carbonitrile 1 is hydrolyzed with sulfuric acid to give 5-amino-1-methyl-1H-imidazole-4-carboxamide 2. Cyclization with urea gives 9-methyl-1H-purine-2,6(3H,9H)-dione 3. Chlorination with phosphorus pentachloride and phosphorusoxychloride gives 2,6-dichloro-9-methyl-9H-purine 4 (CAS Registry 2382-10-7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158625B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f6e82623cba244ebbb77e2a91b118806 |
| Source note | uspto-grants-2012_04 |