2-(4-Piperidyl)-2-propanol → 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol

HRID 1692865Notes

Reaction equation

HRID 1692865 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:10])([CH3:9])[CH3:8])[CH2:3][CH2:2]1.Br[CH2:12][C:13]1[N:14]([CH3:29])[C:15]2[C:20]([N:21]=1)=[C:19]([N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1)[N:18]=[C:17]([Cl:28])[N:16]=2>>[Cl:28][C:17]1[N:16]=[C:15]2[C:20]([N:21]=[C:13]([CH2:12][N:1]3[CH2:6][CH2:5][CH:4]([C:7]([OH:10])([CH3:9])[CH3:8])[CH2:3][CH2:2]3)[N:14]2[CH3:29])=[C:19]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[N:18]=1

Participants

3

Reactant 2

HCID 52003212-(4-Piperidyl)-2-propanolHCID 596034814-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine

Product 1

HCID 596034262-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-olYield 93.2%

Procedure

2-(Piperidin-4-yl)propan-2-ol (0.73 g) was reacted with 4-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine (1.6 g) via General Procedure C to yield 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol (1.76 g) as a white solid.

Sources & evidence

ORD record
ord-ce0b8b9857e141f9826207346dc0777a
Source dataset
uspto-grants-2012_04
Patent number
US08158625B2

Reaction notes

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