HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1692940Generated: October 31, 2026
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 86634347, compound
https://huagongshe.com/reaction/1692940
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 4-(1H-Pyrazol-4-yl)-7-(2-(trimethylsilyl)ethoxy)methyl-7 H-pyrrolo(2,3-d)-pyrimidine | HCID 42631346 | — |
| Reactant | HCID 86634346 | HCID 86634346 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86634347 | HCID 86634347 | — |
Reaction Steps
The crude 2,2′,2″-cyclobutane-1,1-diyl-3-ylidenetriacetonitrile (1 g, 0.006 mol) was combined with 4-(1H-pyrazol-4-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidine (0.2 g, 0.0006 mol) in acetonitrile (10 mL) and 1,8-diazabicyclo[5.4.0]undec-7-ene (0.1 mL, 0.001 mol) was added under nitrogen. The mixture was heated at 50° C. over night. The reaction was concentrated and purified with Combiflash (silica gel, 0-100% EtOAc/Hex) to give the desired product as light brown oil. LCMS calculated for C25H31N8OSi(M+H)+: 487.2; Found: 487.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08158616B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-af1b52319fa8490e829aadeaa52f47dc |
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| Source note | uspto-grants-2012_04 |
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