HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1692948Generated: November 2, 2026
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 178510878, compound
https://huagongshe.com/reaction/1692948
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 4-(1H-Pyrazol-4-yl)-7-(2-(trimethylsilyl)ethoxy)methyl-7 H-pyrrolo(2,3-d)-pyrimidine | HCID 42631346 | — |
| Reactant | (3-{[Tert-butyl(diphenyl)silyl]oxy}cyclobutylidene)acetonitrile | HCID 66824450 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178510878 | HCID 178510878 | — |
Reaction Steps
(3-[tert-Butyl(diphenyl)silyl]oxycyclobutylidene)acetonitrile (0.15 g, 0.00043 mol) was combined with 4-(1H-pyrazol-4-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidine (0.14 g, 0.00043 mol) in acetonitrile (5 mL) and 1,8-diazabicyclo[5.4.0]undec-7-ene (0.064 mL, 0.00043 mol) was added under nitrogen. The mixture was heated to 50° C. over night. LCMS showed a peak with m/z of 425.4, indicating a de-silyl reaction occurred simultaneously during the Micheal addition. The reaction was concentrated and purified on combiflash (silica gel, 0-100% EtOAc/Hex) to yield the desired produt. LCMS (M+H) 425.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08158616B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-4e1f08f4e2264e0dbbedf24f429348ed |
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| Source note | uspto-grants-2012_04 |
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