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2-(Methylthio)-1H-pyrimidin-4-one → 2-(3-(2-methylthiazol-4-yl)phenylamino)pyrimidin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Methylthio)-1H-pyrimidin-4-one | HCID 79823 | — |
| 反応物 | 3-(2-Methyl-thiazol-4-yl)-phenylamine | HCID 736535 | — |
| 溶媒 | Diglyme | HCID 8150 | — |
| 生成物 | 2-(3-(2-methylthiazol-4-yl)phenylamino)pyrimidin-4(3H)-one | HCID 57780911 | 25% |
反応手順
To 2-(methyl-thio)pyrimidine-4(3H)-one, 1, (1 g, 14.08 mmol) in diglyme (9 mL) is added 3-(2-methylthiazol-4-yl)benzenamine (3.20 g, 16.90 mmol). The resulting mixture is heated to reflux and stirred for 18 hours. A solid forms upon cooling the mixture to room temperature. The solid is washed with hexanes to afford 1.0 g (25% yield) of the desired compound. MS (ESI, pos. ion) m/z: 285 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08158641B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-522812e860dc4d1ebf26a57a44ee5a9b |
| 出典メモ | uspto-grants-2012_04 |